Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved.  Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN.  Molecular Therapy, 2009 Jul 21. (Article in Press)

Safety and bio-effects of ultrasound contrast agents.  Gail ter Haar.  Medical and Biological Engineering and Computing, Vol. 47(8), p893-900, August 2009.

 

LIF-Free Embryonic Stem Cell Culture in Simulated Microgravity.  Yumi Kawahara, Tomotaka Manabe, Masaya Matsumoto, Teruyuki Kajiume, Masayasu Matsumoto, and Louis Yuge. PLoS One, Vol. 4(7): e6343, 2009.

 

Ultrasound Exposure of Lipoplex Loaded Microbubbles Facilitates Direct Cytoplasmic Entry of the Lipoplexes.  Ine Lentacker, Nan Wang, Roosmarijn E. Vandenbroucke, Jo Demeester, Stefaan C. De Smedt and Niek N. Sanders.  Mol. Pharmaceutics, Vol. 6 (2), p457–467, 2009.

 

Microbubble compositions, properties and biomedical applications.  S. R. Sirsi, M. A. Borden.  Bubble Science, Engineering & Technology, Vol. 1(1-2), p. 3-17(15), 2009.

 

TGF-β1 + EGF-Initiated Invasive Potential in Transformed Human Keratinocytes Is Coupled to a Plasmin/MMP-10/MMP-1–Dependent Collagen Remodeling Axis: Role for PAI-1.  Cynthia E. Wilkins-Port, Qunhui Ye, Joseph E. Mazurkiewicz, and Paul J. Higgins.  Cancer Research, Vol. 69, p4081, May 2009.

 

Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents.  J.R. Eisenbrey, P. Huang, J. Hsu and M.A. Wheatley.  Ultrasonics.  2009 Mar 28. (Article in Press)

 

Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation.  Bernadet D.M. Meijering, Lynda J.M. Juffermans, Annemieke van Wamel, Rob H. Henning, Inge S. Zuhorn, Marcia Emmer, Amanda M.G. Versteilen, Walter Paulus, Wiek H. van Gilst, Klazina Kooiman, Nico de Jong, Rene J.P. Musters, Leo E. Deelman, Otto Kamp.  Circulation Research, Vol. 104 (5), p679-687, February 2009.

 

Therapeutic potential of low-intensity ultrasound (part 2): biomolecular effects, sonotransfection, and sonopermeabilization.  Loreto B. Feril Jr , Katsuro Tachibana, Yurika Ikeda-Dantsuji, Hitomi Endo, Yoshimi Harada, Takashi Kondo, and Ryohei Ogawa.  J Med Ultrasonics, Vol. 35, p161–167, January 2009.

 

Low magnitude and high frequency mechanical loading prevents decreased bone formation responses of 2T3 preosteoblasts.  Mamta J. Patel, Kyungh Hwa Chang, Michelle C. Sykes, Roger Talish, Clinton Rubin, Hanjoong Jo.  Journal of Cellular Biochemistry, Vol. 106(2), p306 – 316, January 2009.

 

A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction.  Rachel L. Zemans, Natalie Briones, Scott K. Young, Kenneth C. Malcolm, Yosef Refaeli, Gregory P. Downey, G. Scott Worthen.  Journal of Immunological Methods, Vol. 340 (2), p102-115, January 2009.

 

New strategies for nucleic acid delivery to conquer cellular and nuclear membranes. Lentacker I, Vandenbroucke RE, Lucas B, Demeester J, De Smedt SC, Sanders NN.  Journal of Controlled Release. Vol. 132 (3), p279-288, December 2008.

 

Impact of the microgravity environment in a 3-dimensional clinostat on osteoblast- and osteoclast-like cells.  Seicho Makihira, Yumi Kawahara, Louis Yuge, Yuichi Mine and Hiroki Nikawa.  Cell Biology International, Vol. 32(9), p1176-81, September 2008.

 

Delayed Effects of Cold Atmospheric Plasma on Vascular Cells.  Eva Stoffels, Anton J. M. Roks, Leo E. Deelman.  Plasma Processes and Polymers, Vol. 5(6), p599 – 605, July 2008.

 

Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma.  Saminathan S. Nathan, Andrew G. Huvos, Jorge E. Casas-Ganem, Rui Yang, Irina Linkov, Rebecca Sowers, Gene R. DiResta, Richard Gorlick, John H. Healey.  Journal of Orthopaedic Research, Vol. 26 (11), p1520 – 1525, May 2008.  

 

Fabrication of a Neotrachea Using Engineered Cartilage.  Weidenbecher, M., Tucker, H. M., Awadallah, A., and J.E. Dennis.  Laryngoscope, Vol. 118(4), p593-598, April 2008.

 

Low-Intensity Ultrasound-Exposed Microbubbles Provoke Local Hyperpolarization of the Cell Membrane Via Activation of BKCa Channels.  L. Juffermans, O. Kamp, P. Dijkmans, C. Visser, R. Musters.  Ultrasound in Medicine & Biology, Vol. 34(3), p502 – 508.  March 2008.

 

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles.   Roosmarijn E. Vandenbroucke, Ine Lentacker, Joseph Demeester, Stefaan C. De Smedt and Niek N. Sanders.  Journal of Controlled Release, Vol. 126(3), p265-273, March 2008.

 

Evaluation of the gene for inducible nitric oxide synthase as a radiosensitizer under hypoxic and oxic conditions.  M. Turek¹ School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA, M. Padilla,¹ School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA and D. J. Argyle, Veterinary and Comparative Oncology, Vol. 5(4), p250–255, December 2007.

 

Optimization of ultrasound and microbubbles targeted gene delivery to cultured primary endothelial cells.  Meijering BD, Henning RH, Van Gilst WH, Gavrilovic I, Van Wamel A, Deelman LE.  J Drug Target. Vol. 15(10), p664-671, December 2007.

 

Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer.  Niek N. Sanders, Liesbeth Peeters, Ine Lentacker, Joseph Demeester and Stefaan C. De Smedt.  Journal of Controlled Release, Vol. 122(3), p226-235, October 2007.

 

Lipoplex-Loaded Microbubbles for Gene Delivery: A Trojan Horse Controlled by Ultrasound.  I. Lentacker, S. C. De Smedt, J. Demeester, V. Van Marck, M. Bracke, and N. N. Sanders.  Advanced Functional materials, Vol. 17(12), p1910-1916, August 2007.

 

Changes in microbubble dynamics near a boundary revealed by combined optical micromanipulation and high-speed imaging.  V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. L. J. Overvelde, S. M. van der Meer, N. de Jong, D. Lohse, and M. Versluis.  Applied Physics Letters Vol. 90 (11), 114103, March 2007.

PAI-1 is a Critical Upstream Regulator of the TGF-β1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma.  Cynthia E. Wilkins-Port, Craig E. Higgins, Jennifer Freytag, Stephen P. Higgins, J. Andrew Carlson, and Paul J. Higgins.  J Biomed Biotechnol. Vol. 2007; 2007: 85208. Published online 2007 March 20.

 

Targeted retroviral gene delivery using ultrasound.  Sarah L. Taylor, Ahad A. Rahim, Nigel L. Bush, Jeffrey C. Bamber, Colin D. Porter.  The Journal of Gene Medicine, Vol. 9(2), p77-87. Feb 2007.

 

Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine.  Mamta J. Patel, Wenbin Liu, Michelle C. Sykes, Nancy E. Ward, Semyon A. Risin, Diana Risin, Hanjoong Jo.  Journal of Cellular Biochemistry, Vol. 101(3), p587 – 599, January 2007.

 

Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours.  Petra Haaga, Ferdinand Frauscherb, Johann Gradlb, Alexander Seitzb, Georg Schäferc, Jonathan R. Lindnerd, Alexander L. Klibanove, Georg Bartscha, Helmut Klockera and Iris E. Eder.  The Journal of Steroid Biochemistry and Molecular Biology, Vol. 102(1-5), p103-113, December 2006.

 

Cobalt nano-particles modulate cytokine in vitro release by human mononuclear cells mimicking autoimmune disease.  Petrarca C, Perrone A, Verna N, Verginelli F, Ponti J, Sabbioni E, Di Giampaolo L, Dadorante V, Schiavone C, Boscolo P, Mariani Costantini R, Di Gioacchino M.  Int J Immunopathol Pharmacol. Vol. 19(4 Suppl), p11-4, Oct-Dec 2006.

 

Caveolae and caveolae constituents in mechanosensing - Effect of modeled microgravity on cultured human endothelial cells.  Enzo Spisni, Mattia Toni, Antonio Strillacci, Grazia Galleri, Spartaco Santi, Cristiana Griffoni, and Vittorio Tomasi.  Cell Biochemistry and Biophysics, Vol. 46(2), p 155-164, October, 2006.

 

Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide.  L.J.M. Juffermans, P.A. Dijkmans, R.J.P. Musters, C.A. Visser, and O. Kamp.  Am J Physiol Heart Circ Physiol. Vol. 291(4), p1595-601, (Epub 2006 Apr 21), October 2006.

 

Multi Modal Contrast Agents.  Kenneth L. Watkin.  Online publication at http://www.sns.gov/workshops/ian2006/TU2/IAN2006oct_klw.pdf. October 2006.

 

1F-2 Optical Trapping of Ultrasound Contrast Agent Microbubbles: Study of the Bubble-Wall and Bubble-Bubble Interaction in Ultrasound.  Garbin V., Ferrari E., Cojoc D., Di Fabrizio E., Overvelde M.L.J., van der Meer S.M., Versluis M., de Jong N., Lohse D.  Ultrasonics Symposium 2006. IEEE, p513-516, Oct. 2006.

 

Spatial and acoustic pressure dependence of microbubble-mediated gene delivery targeted using focused ultrasound.  Ahad A. Rahim, Sarah L. Taylor, Nigel L. Bush, Gail R. ter Haar, Jeffrey C. Bamber, Colin D. Porter.  The Journal of Gene Medicine, Vol. 8(11), p1347 – 1357, Published Online 2006 September 18.

 

Physical parameters affecting ultrasound/microbubble-mediated gene delivery efficiency in vitro.  Rahim A., Taylor S., Bush N., ter Haar G., Bamber J., Porter C.. Ultrasound in Medicine & Biology, Vol. 32 (8), p1269-1279, August 2006.

 

Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation.  Annemieke van Wamel, Klazina Kooiman, Miranda Harteveld, Marcia Emmer, Folkert J. ten Cate, Michel Versluis and Nico de Jong.  Journal of Controlled Release Vol. 112 (2), p149-155, May 2006.

 

In vitro detection of hepatocytotoxic metabolites from Drechslera biseptata: a contributing factor to acute bovine liver desease?  M. R. Aslani, I. Pascoe, M. Kowalski, A. Michalewicz, M. A. S. Retallick and S. M. Colegate.   Australian Journal of Experimental Agriculture. Vol. 46(5), p599–604, May 2006.

 

Ultrasound Microbubble Induced Endothelial Cell Permeability.  A. van Wamel, K. Kooiman, M. Emmer, F.J. ten Cate, M. Versluis, and N. de Jong.  Ninth European Symposium on Controlled Drug Delivery Program, p249-252, April 2006.

 

Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili.  R. Randal Bollingera, b, Mary Lou Everetta, Shaina D. Wahla, Yu-Huei Leea, Paul E. Orndorffc and William Parker.  Molecular Immunology, Vol. 43(4), p378-387, February 2006.

 

Toward Complete Laser Ablation of Melanoma Contaminant Cells in a Co-culture Outgrowth Model Via Image Cytometry.  Feimo Shen and Jeffrey H. Price.  Cytometry Part A,  Vol. 69A, p573–581, 2006.

 

Monitoring the frozen state of freezing media by using millimeter waves.  M. Mizuno, C. Otani, K. Kawase, Y. Kurihara, K. Shindo, Y. Ogawa, H. Matsuki.  Journal of Electromagnetic Waves and Applications, Vol. 20(3), p. 341-349, 2006.

 

UV excimer lamp irradiation of fibroblasts: the influence on antioxidant homeostasis.  Erofeev MV, Kieft IE, Sosnin EA, Stoffels E.  IEEE Transactions on Plasma Science, Vol. 34(4), p1359-1364, 2006. 

 

A novel 3-dimensional culture system as an in vitro model for studying oral cancer cell invasion.  H.S. Duong, A.D. Le, Q. Zhang, D.V. Messadi.  Int J Exp Pathol. Vol. 86(6), p365-374, December 2005.

 

Monoclonal Antibodies to Ricin: In Vitro Inhibition of Toxicity and Utility as Diagnostic Reagents. Mark T. Dertzbaugh, Cynthia A. Rossi, Brian M. Paddle, Martha Hale, Michael Poretski, Malcolm R. Alderton. Hybridoma, Vol. 24 (5), p236-243, October 2005.

 

Cell Proliferation of Cultured Human Cancer Cells are affected by the Elevated Tumor Pressures that exist in vivo. Gene R. DiResta, Saminathan S. Nathan, Mark Manoso, Jorge Casas-Ganem, Chris Wyatt, Tadaheko Kubo, Patrick Boland, Edward Athanasian, Jonathan Miodownik, Richard Gorlick, and John H. Healey. Annals of Biomedical Engineering, Vol. 33(9), p1270-1280, September 2005.

 

Methods for the Culture of C. Elegans and S. Cerevisiae in Microgravity. Thomas Fahlen, June Sunga, Jon Rask, Anna Herrera, Kitty Lam, Luke Sing, Kevin Sato, Ross A. Ramos, Melissa Kirven-Brooks, and Debra Reiss-Bubenheim. Gravitational and Space Biology, Vol. 18(2), p91-92, June 2005. 

 

Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts. Steven J. Pardo, Mamta J. Patel, Michelle C. Sykes, Manu O. Platt, Nolan L. Boyd, George P. Sorescu, Min Xu, Jack J. W. A. van Loon, May D. Wang, and Hanjoong Jo.  American Journel of Physiology - Cell Physiology, Vol. 288, p1211 – 1221, June 2005.

 

A microfluidic shadow imaging system for the study of the nematode Caenorhabditis elegans in space.  Dirk Lange, Christopher W. Storment, Catharine A. Conley and Gregory T.A. Kovacs.  Sensors and Actuators B: Chemical, Vol. 107(2), p904-914, June 2005.

 

Nano-Particles and Targeted Delivery Using Ultrasound. Kenneth L. Watkin. On line publication at http://ncl.cancer.gov/about_ncl/event_2005-5-19_nanoparticles-ultrasound.pdf. 2005. 

 

Effects of the gravity on intracellular transport in neuronal cells. Shinichi Mitsui and Nozomi Yamaguchi. On line publication at http://www4.jsforum.or.jp/public/report/h14_report/h130172mitsui/h130172mitsui_e.pdf. 2005.

 

Elevated Physiological Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma. Saminathan S Nathan, Gene R DiResta, Jorge E Casas-Ganem, Bang H Hoang, Rebecca Sowers, Rui Yang, Andrew G Huvos, Richard Gorlick and John H Healey. Clinical Cancer Research Vol. 11, 2389-2397, March 2005. 

 

Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction. van Wamel A, Bouakaz A, Versluis M, de Jong N. Ultrasound in Medicine & Biology. Vol. 30(9), p1255-8, September 2004. 

 

Remote manipulation of cells with ultrasound and microbubbles. van Wamel A, Bouakaz A, Versluis M, de Jong N. Ultrasonics Symposium, 2004 IEEE, Vol. 2, p1094 – 1097, Aug 2004. 

 

Influence of topology on bacterial social interaction. Park S, Wolanin PM, Yuzbashyan EA, Lin H, Darnton NC, Stock JB, Silberzan P and Austin R. Proc Natl Acad Sci U S A. Vol. 100, No. 24, p13910-13915, November 2003. 

 

Chemically defined medium and Caenorhabditis elegans. Nathaniel J Szewczyk, Elena Kozak and Catharine A Conley. BMC Biotechnology. Vol. 3, No.19, October 2003.

 

DNA Transfer and Cell Killing in Epidermoid Cells by Diagnostic Ultrasound Activation of Contrast Agent Gas Bodies In Vitro. Douglas LM, Chunyan D and Song J, Ultrasound in Medicine & Biology. Vol. 29, No. 4, p601-607, April 2003. 

 

Preliminary Study of Mouse Embryonic Stem Cell Differentiation Influenced by PFSK Cells Using an OptiCell Device. Ashton E and Capco DG. Online publication at http://ls.la.asu.edu/bio494/dcapco/ 2002. 

 

Vascular Endothelial Growth Factor Secretion by Tumor-infiltrating Macrophages Essentially Supports Tumor Angiogenesis, and IgG Immune Complexes Potentiate the Process. Emilio Barbera-Guillem, Julie K. Nyhus, Chris C. Wolford, Chad R. Friece, and James W. Sampsel. Cancer Research. Vol. 62, p7042-7049, December 2002. 

 

High performance imagaing of living and fixed cells cultured in OptiCell. Emilio Barbera-Guillem, M.D. Ph.D., Biomedical Products, Vol. 26, No. 8, August 2001.

 

Current trends and innovations in cell culture. Vicki Glaser, Genetic Engineering News, Vol. 21 No.11, June 2001. 

 

OptiCell - Building block for in vitro pharmacokinetic and pharmacodynamic studies. Emilio Barbera-Guillem, M.D. Ph.D., Innovations in Pharmaceutical Technology, p50-51. June 2001.

 

Overcoming cell culture barriers to meet the demands of cell biology and biotechnology. Emilio Barbera-Guillem, M.D. Ph.D., American Biotechnology Laboratory, May 2001.

 

OptiCell Concept for Cell Culture Operations - Novel Technology for Cell Growth and Monitoring. Emilio Barbera-Guillem, M.D. Ph.D. and John M. Swartz, Ph.D., Genetic Engineering News, Vol. 20, No.21, December 2000.